HMGB3P12

Across TCGA pan-cancer cohorts, HMGB3P12 RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated HMGB3P12 data layer.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher HMGB3P12 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated HMGB3P12 expression acts as an unfavorable survival marker, although some lineages such as OV show a favorable association.

COAD, ACC, and READ are the cancer types where HMGB3P12 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Tertile	II,III,IV	0.146	0.605	<.001	126	view →
ACC	DFS	Tertile	All	0.050	0.675	<.001	87	view →
READ	DFS	Tertile	All	0.082	0.845	<.001	36	view →
GBM	OS	Tertile	All	0.069	0.415	<.001	18	view →
PCPG	DFS	Tertile	All	0.749	0.928	.009	18	view →
OV	OS	Tertile	II,III,IV	0.881	0.830	.019	18	view →
SKCM	DFS	Tertile	IV	0.016	0.454	<.001	18	view →
SARC	OS	Tertile	All	0.619	0.879	.003	9	view →
THYM	DFS	Tertile	III,IV	0.205	0.772	.032	9	view →
KIRP	OS	Tertile	All	0.425	0.716	.015	9	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

HMGB3P12–COAD (OS)

Open the COAD breakdown →