ABCB1

Across TCGA patient cohorts, ABCB1 mutation is significantly associated with the total protein of many other genes, with 76 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ABCB1-associated genes across cancer lineages are ASNS, c-Kit, and JNK_pT183_Y185. Each is linked with ABCB1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ABCB1-to-partner and partner-to-ABCB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by ABCB1-low versus ABCB1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ABCB1→partner) and Y-score (partner→ABCB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.487	+2.123	.001	.010	3	4
STAD	c-Kit →	-0.362	-3.700	.006	.001	3	4
STAD	JNK_pT183_Y185 →	-0.131	-2.979	.006	.033	3	3
COAD	Caspase-7-cleavedD198 →	+1.365	+2.815	<.001	.001	3	3
UCEC	Cyclin-B1 →	+0.574	+2.321	<.001	<.001	3	3
LUSC	A-Raf_pS299 →	+0.203	+1.424	.016	.028	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

ASNS by ABCB1 expression — COAD

Explore this box plot interactively →