ABCB1

Across TCGA pan-cancer cohorts, ABCB1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ABCB1 data layer compared with 24 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ABCB1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ABCB1 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

PDAC, LSCC, and CCRCC are the cancer types where ABCB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	II,III,IV	0.960	0.591	.007	9	view →
LSCC	DFS	Median	II,III,IV	0.854	0.971	.027	6	view →
CCRCC	DFS	Median	II,III,IV	0.814	0.988	.029	6	view →
UCEC	OS	Tertile	II,III,IV	0.645	1.000	.045	4	view →
HNSC	OS	Quartile	All	0.921	1.000	.026	2	view →
GBM	DFS	Median	All	0.271	0.465	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

ABCB1–PDAC (OS)

Open the PDAC breakdown →