ubiquitin specific peptidase 54Genealiases: C10orf29 · bA137L10.3 · bA137L10.4
Q-omics provides the consensus-scored USP54 profile across patient tissues and cancer cell-line models. USP54 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, USP54 is differentially expressed in 12, with the highest sampling consensus in THCA. Additionally, USP54 RNA expression shows 20,694 significant gene co-expression associations, with the highest sampling consensus in KIRP. Together, these results highlight HNSC, THCA, and KIRP as cancer lineages where USP54 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for USP54 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes USP54 survival associations across molecular data types. USP54 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (8) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible USP54 RNA expression–survival associations across cancer types. High USP54 expression shows unfavorable associations in LIHC, MESO and ACC, but favorable associations in HNSC, LUAD and LGG. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for USP54 RNA expression.
This table summarizes USP54 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 4. The strongest signals are observed in THCA for RNA and PDAC for protein.
This table ranks reproducible tumor–normal expression differences for USP54. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. USP54 shows lower tumor expression in THCA, KIRC, KICH, BLCA and LUSC and higher tumor expression in LIHC. The THCA box plot shows higher USP54 RNA expression in normal versus tumor tissue (log2 FC = −1.545, t-test p < 0.001).
This table shows molecular features associated with USP54 in patient tissues and cancer cell lines. In patient samples, USP54 shows the broadest associations at the RNA and protein expression levels, with KIRP recurring as the lineage with the largest associated feature set. In cancer cell lines, USP54 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_NSCLC_LUAD, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Leukemia and BLOOD_Lymphoma.
