USP54

Across TCGA pan-cancer cohorts, USP54 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated USP54 data layer compared with 8 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher USP54 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated USP54 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, LUAD, and LIHC are the cancer types where USP54 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.753	0.636	<.001	89	view →
LUAD	OS	Median	All	0.856	0.766	<.001	73	view →
LIHC	DFS	Median	All	0.455	0.624	<.001	54	view →
MESO	OS	Tertile	All	0.329	0.572	.009	51	view →
ACC	DFS	Tertile	All	0.449	0.830	<.001	45	view →
LGG	OS	Tertile	All	0.949	0.844	<.001	36	view →
KIRC	DFS	Median	IV	0.631	0.285	.004	35	view →
UVM	DFS	Median	All	0.331	0.722	.002	34	view →
UCEC	DFS	Quartile	IV	0.850	0.353	.001	32	view →
BLCA	DFS	Tertile	III,IV	0.096	0.472	.011	24	view →
UCS	DFS	Median	IV	0.952	0.367	.001	24	view →
SCLC	DFS	Median	II,III,IV	0.833	0.190	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

USP54–HNSC (DFS)

Open the HNSC breakdown →