USP54

Across TCGA pan-cancer cohorts, USP54 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of USP54’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where USP54 RNA is repressed in tumor relative to normal tissue. In most cancer types USP54 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and KICH are the cancer types where USP54 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in USP54 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.545	<.001	11	view →
KIRC	Male	II,III,IV	−0.717	<.001	11	view →
KICH	Female	All	−1.424	<.001	8	view →
LIHC	All	II,III,IV	+0.982	<.001	8	view →
BLCA	All	III,IV	−0.758	.001	8	view →
LUSC	Female	II,III,IV	−1.434	<.001	7	view →
LUAD	All	All	−0.738	<.001	7	view →
HNSC	All	II,III,IV	−0.697	<.001	7	view →
UCEC	All	III,IV	+1.173	<.001	6	view →
CHOL	Male	All	+2.248	<.001	5	view →
COAD	Male	All	+0.468	.006	3	view →
PRAD	All	All	+0.805	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

USP54–THCA

Open the THCA breakdown →