USP54

Across TCGA cell cohorts, USP54 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,590 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible USP54-associated GO terms across cancer lineages are Viral translational termination-reinitiation, Vacuolar transport, and Cytosolic transport. Each is linked with USP54 in more than 15 cancer types. Because this analysis shows association rather than direction, both USP54-to-partner and partner-to-USP54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Viral translational termination-reinitiation grouped by USP54-low versus USP54-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (USP54→partner) and Y-score (partner→USP54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Viral translational termination-reinitiation →	+0.107	+1.323	.001	.001	3	16
STOMACH	Vacuolar transport →	+0.052	+1.259	.001	.001	3	15
OESOPHAGUS	Cytosolic transport →	+0.064	+1.096	.004	.003	3	14
OESOPHAGUS	Cilium movement involved in cell motility →	-0.115	-1.468	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Phospholipid biosynthetic process →	+0.052	+1.024	<.001	.007	3	14
UPPER_AERODIGESTIVE_TRACT	Vesicle-mediated transport to the plasma membrane →	+0.076	+1.226	<.001	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,590 associations by consensus.

Viral translational termination-reinitiation by USP54 expression — UPPER_AERODIGESTIVE_TRACT

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