USP54

Across TCGA cell cohorts, USP54 mutation is significantly associated with the RNA expression of many other genes, with 66 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible USP54-associated genes across cancer lineages are DCANP1, OR6J1, and ARHGEF15. Each is linked with USP54 in more than 1 cancer types. Because this analysis shows association rather than direction, both USP54-to-partner and partner-to-USP54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCANP1 grouped by USP54-low versus USP54-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP54→partner) and Y-score (partner→USP54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DCANP1 →	+0.011	+2.669	<.001	.004	3	2
BLOOD_Leukemia	OR6J1 →	+0.029	+2.971	<.001	.003	3	2
BLOOD_Myeloma	ARHGEF15 →	+0.050	+4.807	<.001	.006	3	1
SOFT_TISSUE	RPL10L →	+0.038	+4.930	<.001	.008	3	1
SOFT_TISSUE	C12orf40 →	+0.383	+4.930	<.001	.008	3	1
LUNG_NSCLC_LUAD	OR12D3 →	+0.029	+4.228	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

DCANP1 by USP54 expression — LARGE_INTESTINE

Explore this box plot interactively →