USP54

Across TCGA patient cohorts, USP54 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USP54-associated genes across cancer lineages are ATM, eIF4E, and JNK2. Each is linked with USP54 in more than 3 cancer types. Because this analysis shows association rather than direction, both USP54-to-partner and partner-to-USP54 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by USP54-low versus USP54-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USP54→partner) and Y-score (partner→USP54) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.533	-2.000	<.001	<.001	3	4
UCEC	eIF4E →	+0.203	+4.013	<.001	<.001	3	2
UCEC	JNK2 →	+0.165	+1.398	.003	.004	3	2
UCEC	Notch1 →	+0.116	+1.257	.003	.027	3	2
UCEC	p27_pT198 →	+0.070	+1.440	.021	.022	3	2
UCEC	p62 Lck ligand →	+0.315	+1.784	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

ATM by USP54 expression — UCEC

Explore this box plot interactively →