USP54

Across TCGA pan-cancer cohorts, USP54 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated USP54 data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher USP54 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated USP54 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where USP54 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.872	0.381	<.001	20	view →
PDAC	OS	Tertile	III,IV	0.149	0.915	.017	12	view →
LUAD	DFS	Quartile	III,IV	0.323	0.731	.012	6	view →
GBM	OS	Tertile	All	0.584	0.377	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

USP54–LSCC (DFS)

Open the LSCC breakdown →