TUB like protein 1Genealiases: LCA15 · RP14 · TUBL1
Q-omics provides the consensus-scored TULP1 profile across patient tissues and cancer cell-line models. TULP1 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, TULP1 is differentially expressed in 10, with the highest sampling consensus in KIRC. Additionally, TULP1 RNA expression shows 14,914 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight HNSC, KIRC, and THYM as cancer lineages where TULP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TULP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TULP1 survival associations across molecular data types. TULP1 RNA expression shows survival associations in the most cancer types (23), followed by mutation status (9) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TULP1 RNA expression–survival associations across cancer types. High TULP1 expression shows unfavorable associations in KIRP, KIRC, SKCM and UCEC, but favorable associations in HNSC and UCS. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for TULP1 RNA expression.
This table summarizes TULP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 1. The strongest signals are observed in KIRC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for TULP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TULP1 shows lower tumor expression in KIRC, KICH, BRCA and PRAD and higher tumor expression in LUSC and LUAD. The KIRC box plot shows higher TULP1 RNA expression in normal versus tumor tissue (log2 FC = −0.072, t-test p < 0.001).
This table shows molecular features associated with TULP1 in patient tissues and cancer cell lines. In patient samples, TULP1 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, TULP1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BONE, while CRISPR and shRNA rows add functional-dependency signals in URINARY_TRACT and BREAST.
