TULP1

Across TCGA patient cohorts, TULP1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TULP1-associated genes across cancer lineages are BRCA2, 14-3-3_beta, and ERCC1. Each is linked with TULP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TULP1-to-partner and partner-to-TULP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BRCA2 grouped by TULP1-low versus TULP1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TULP1→partner) and Y-score (partner→TULP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	BRCA2 →	-0.174	-3.321	.024	.009	3	2
SKCM	14-3-3_beta →	-0.154	-1.906	.002	.016	3	1
SKCM	ERCC1 →	+0.139	+2.584	.033	.010	3	1
SKCM	ACC_pS79 →	+0.244	+2.459	.036	.018	3	1
SKCM	FOXO3a →	-0.115	-2.459	.012	.017	3	1
SKCM	GAPDH →	+0.469	+2.321	.045	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

BRCA2 by TULP1 expression — SKCM

Explore this box plot interactively →