Q-omics provides the consensus-scored BRCA2 profile across patient tissues and cancer cell-line models. BRCA2 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, BRCA2 is differentially expressed in 15, with the highest sampling consensus in HNSC. Additionally, BRCA2 protein abundance shows 25,874 significant protein co-abundance associations, with the highest sampling consensus in HNSC. Together, these results highlight ACC, and HNSC as cancer lineages where BRCA2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for BRCA2 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes BRCA2 survival associations across molecular data types. BRCA2 RNA expression shows survival associations in the most cancer types (26), followed by mutation status (10) and mass-spec protein abundance (10). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible BRCA2 RNA expression–survival associations across cancer types. High BRCA2 expression shows unfavorable associations in ACC, KIRP, KICH, UVM and LGG, but favorable associations in KIRC. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for BRCA2 RNA expression.
This table summarizes BRCA2 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15, while mass-spec protein shows differences in 8. The strongest signals are observed in KIRC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for BRCA2. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. BRCA2 shows higher tumor expression in HNSC, KIRC, BLCA, COAD, KIRP and STAD. The HNSC box plot shows higher BRCA2 RNA expression in tumor versus normal tissue (log2 FC = +1.279, t-test p < 0.001).
This table shows molecular features associated with BRCA2 in patient tissues and cancer cell lines. In patient samples, BRCA2 shows the broadest associations at the RNA and protein expression levels, with HNSC recurring as the lineage with the largest associated feature set. In cancer cell lines, BRCA2 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LARGE_INTESTINE, while CRISPR and shRNA rows add functional-dependency signals in LUNG_NSCLC_LUAD and BLOOD_Leukemia.
