BRCA2

Across TCGA cell cohorts, BRCA2 mutation is significantly associated with the RNA expression of many other genes, with 2,535 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BRCA2-associated genes across cancer lineages are PIGL, TMEM174, and SLC25A39. Each is linked with BRCA2 in more than 2 cancer types. Because this analysis shows association rather than direction, both BRCA2-to-partner and partner-to-BRCA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIGL grouped by BRCA2-low versus BRCA2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRCA2→partner) and Y-score (partner→BRCA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PIGL →	+0.764	+3.700	<.001	<.001	3	3
BLOOD_Lymphoma	TMEM174 →	+0.162	+2.321	.001	.008	3	3
LARGE_INTESTINE	SLC25A39 →	+0.311	+2.409	.006	.003	3	3
LARGE_INTESTINE	TTC5 →	+0.509	+2.526	.005	.002	3	3
LARGE_INTESTINE	WRN →	+0.830	+2.364	<.001	<.001	3	3
LARGE_INTESTINE	ZNF518A →	+0.581	+2.321	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,535 associations by consensus.

PIGL by BRCA2 expression — LARGE_INTESTINE

Explore this box plot interactively →