BRCA2

Across TCGA pan-cancer cohorts, BRCA2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of BRCA2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where BRCA2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BRCA2 is over-expressed in tumor.

HNSC, KIRC, and BLCA are the cancer types where BRCA2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BRCA2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.279	<.001	12	view →
KIRC	Male	All	+0.865	<.001	12	view →
BLCA	Male	III,IV	+1.870	<.001	11	view →
COAD	Male	IV	+1.502	<.001	11	view →
KIRP	All	III,IV	+0.847	<.001	11	view →
STAD	All	III,IV	+1.523	<.001	9	view →
LIHC	All	III,IV	+0.595	<.001	9	view →
UCEC	All	III,IV	+1.444	<.001	8	view →
BRCA	All	III,IV	+1.120	<.001	8	view →
LUAD	Male	All	+0.822	<.001	8	view →
READ	All	All	+1.317	<.001	7	view →
LUSC	Male	II,III,IV	+1.065	<.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

BRCA2–HNSC

Open the HNSC breakdown →