BRCA2

Across TCGA patient cohorts, BRCA2 mutation is significantly associated with the total protein of many other genes, with 90 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRCA2-associated genes across cancer lineages are ACVRL1, p70-S6K, and Caspase-7-cleavedD198. Each is linked with BRCA2 in more than 3 cancer types. Because this analysis shows association rather than direction, both BRCA2-to-partner and partner-to-BRCA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACVRL1 grouped by BRCA2-low versus BRCA2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRCA2→partner) and Y-score (partner→BRCA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ACVRL1 →	-0.214	-1.991	.034	.031	3	4
STAD	p70-S6K →	+0.320	+3.584	.003	.002	3	4
UCEC	Caspase-7-cleavedD198 →	+0.373	+1.398	.009	.004	3	4
STAD	MYH11 →	-1.709	-2.321	.007	.032	3	3
STAD	E-Cadherin →	+0.763	+2.459	.026	.019	3	3
STAD	c-Kit →	-0.420	-3.169	.002	.017	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 90 associations by consensus.

ACVRL1 by BRCA2 expression — COAD

Explore this box plot interactively →