BRCA2

Across TCGA patient cohorts, BRCA2 mutation is significantly associated with the RNA expression of many other genes, with 5,768 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BRCA2-associated genes across cancer lineages are NCAPD3, HPGDS, and STOML2. Each is linked with BRCA2 in more than 3 cancer types. Because this analysis shows association rather than direction, both BRCA2-to-partner and partner-to-BRCA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCAPD3 grouped by BRCA2-low versus BRCA2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BRCA2→partner) and Y-score (partner→BRCA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NCAPD3 →	+0.539	+1.332	<.001	<.001	3	4
UCEC	HPGDS →	-0.248	-1.523	.002	.006	3	4
UCEC	STOML2 →	+0.303	+1.530	<.001	<.001	3	4
STAD	MRPL16 →	+0.510	+3.334	.001	.005	3	4
UCEC	CHAF1A →	+0.596	+2.606	<.001	<.001	3	4
UCEC	HINT1 →	+0.422	+1.424	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,768 associations by consensus.

NCAPD3 by BRCA2 expression — UCEC

Explore this box plot interactively →