BRCA2

Across TCGA pan-cancer cohorts, BRCA2 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated BRCA2 data layer compared with 26 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher BRCA2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated BRCA2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

THYM, UCEC, and ESCA are the cancer types where BRCA2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
UCEC	DFS	Median	All	0.985	0.593	<.001	36	view →
ESCA	DFS	Median	All	0.208	0.540	.006	24	view →
KIRP	DFS	Median	IV	0.088	0.502	<.001	15	view →
BRCA	OS	Median	III,IV	0.514	0.906	.001	10	view →
SARC	DFS	Median	All	0.173	0.612	.020	6	view →
PRAD	DFS	Median	All	0.617	0.886	.045	6	view →
LGG	DFS	Median	All	0.192	0.728	.007	3	view →
BLCA	DFS	Median	III,IV	0.555	0.259	.035	3	view →
STAD	DFS	Median	II,III,IV	0.786	0.366	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

BRCA2–THYM (OS)

Open the THYM breakdown →