BRCA2

Across TCGA cell cohorts, BRCA2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,380 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible BRCA2-associated GO terms across cancer lineages are Replication fork processing, DNA-templated DNA replication maintenance of fidelity, and Centrosome duplication. Each is linked with BRCA2 in more than 19 cancer types. Because this analysis shows association rather than direction, both BRCA2-to-partner and partner-to-BRCA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Replication fork processing grouped by BRCA2-low versus BRCA2-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BRCA2→partner) and Y-score (partner→BRCA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Replication fork processing →	+0.119	+1.052	.001	<.001	3	20
BONE	DNA-templated DNA replication maintenance of fidelity →	+0.151	+1.333	<.001	<.001	3	20
BONE	Centrosome duplication →	+0.166	+1.481	<.001	<.001	3	20
OVARY	Mitotic sister chromatid cohesion →	+0.158	+1.372	<.001	<.001	3	20
BONE	Double-strand break repair via synthesis-dependent strand annealing →	+0.106	+1.029	.005	.008	2	20
OESOPHAGUS	DNA recombination →	+0.106	+1.203	.001	.003	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,380 associations by consensus.

Replication fork processing by BRCA2 expression — OESOPHAGUS

Explore this box plot interactively →