tubulin beta 4A class IVaGenealiases: DYT4 · TUBB4 · beta-5
Q-omics provides the consensus-scored TUBB4A profile across patient tissues and cancer cell-line models. TUBB4A expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, TUBB4A is differentially expressed in 12, with the highest sampling consensus in COAD. Additionally, TUBB4A protein abundance shows 25,805 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight UVM, COAD, and GBM as cancer lineages where TUBB4A shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TUBB4A — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TUBB4A survival associations across molecular data types. TUBB4A RNA expression shows survival associations in the most cancer types (22), followed by mutation status (4) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TUBB4A RNA expression–survival associations across cancer types. High TUBB4A expression shows unfavorable associations in UCEC, STAD and SKCM, but favorable associations in UVM, HNSC and KIRP. The UVM Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for TUBB4A RNA expression.
This table summarizes TUBB4A tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 6. The strongest signals are observed in COAD for RNA and COAD for protein.
This table ranks reproducible tumor–normal expression differences for TUBB4A. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TUBB4A shows lower tumor expression in COAD, KICH and READ and higher tumor expression in KIRP, LIHC and LUSC. The COAD box plot shows higher TUBB4A RNA expression in normal versus tumor tissue (log2 FC = −1.664, t-test p < 0.001).
This table shows molecular features associated with TUBB4A in patient tissues and cancer cell lines. In patient samples, TUBB4A shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, TUBB4A RNA and mutation anchors are most strongly linked to RNA-expression features, especially in CNS, while CRISPR and shRNA rows add functional-dependency signals in PANCREAS and BONE.
