TUBB4A

Across TCGA pan-cancer cohorts, TUBB4A RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TUBB4A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TUBB4A RNA is repressed in tumor relative to normal tissue. In most cancer types TUBB4A is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KIRP, and KICH are the cancer types where TUBB4A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TUBB4A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−1.664	<.001	11	view →
KIRP	Male	II,III,IV	+2.818	<.001	7	view →
KICH	All	II,III,IV	−1.287	<.001	6	view →
LIHC	All	All	+1.271	<.001	6	view →
READ	Female	All	−2.168	<.001	5	view →
LUSC	Male	II,III,IV	+1.638	<.001	5	view →
LUAD	All	All	+0.623	<.001	5	view →
STAD	All	All	−0.975	.004	4	view →
BRCA	Female	All	+0.274	.007	4	view →
PAAD	All	All	−1.627	.013	2	view →
PRAD	All	All	+1.013	<.001	2	view →
BLCA	All	IV	−0.498	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TUBB4A–COAD

Open the COAD breakdown →