TUBB4A

Across TCGA cell cohorts, TUBB4A mutation is significantly associated with the RNA expression of many other genes, with 147 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TUBB4A-associated genes across cancer lineages are KNCN, GPR33, and KRTAP19-7. Each is linked with TUBB4A in more than 1 cancer types. Because this analysis shows association rather than direction, both TUBB4A-to-partner and partner-to-TUBB4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KNCN grouped by TUBB4A-low versus TUBB4A-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBB4A→partner) and Y-score (partner→TUBB4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KNCN →	+0.042	+3.700	<.001	.005	3	1
STOMACH	GPR33 →	+0.030	+4.129	<.001	.007	3	1
STOMACH	KRTAP19-7 →	+0.047	+4.285	<.001	.007	3	1
STOMACH	USP17L17 →	+0.010	+4.285	<.001	.007	3	1
LARGE_INTESTINE	C12orf57 →	+0.900	+3.212	.002	.006	3	1
LARGE_INTESTINE	ARL1 →	+0.476	+3.064	.009	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 147 associations by consensus.

KNCN by TUBB4A expression — OVARY

Explore this box plot interactively →