TUBB4A

Across TCGA pan-cancer cohorts, TUBB4A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TUBB4A data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TUBB4A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TUBB4A expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and HNSC are the cancer types where TUBB4A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	III,IV	0.962	0.599	.007	17	view →
CCRCC	DFS	Tertile	All	0.958	0.426	.006	15	view →
HNSC	OS	Median	All	1.000	0.449	.023	12	view →
UCEC	OS	Quartile	All	0.787	1.000	.017	12	view →
LUAD	OS	Quartile	III,IV	0.839	0.233	.011	4	view →
LSCC	OS	Median	II,III,IV	0.810	1.000	.035	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TUBB4A–PDAC (OS)

Open the PDAC breakdown →