TUBB4A

Across TCGA pan-cancer cohorts, TUBB4A mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TUBB4A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TUBB4A mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TUBB4A is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, HNSC, and CCRCC are the cancer types where TUBB4A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TUBB4A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−2.088	<.001	12	view →
HNSC	Male	IV	−1.439	<.001	12	view →
CCRCC	Female	II,III,IV	−1.204	<.001	9	view →
PDAC	Female	II,III,IV	−1.931	<.001	8	view →
LUAD	All	II,III,IV	−0.377	.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TUBB4A–COAD

Open the COAD breakdown →