TUBB4A

Across TCGA patient cohorts, TUBB4A mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUBB4A-associated genes across cancer lineages are Caspase-7-cleavedD198, Notch1, and Annexin-1. Each is linked with TUBB4A in more than 2 cancer types. Because this analysis shows association rather than direction, both TUBB4A-to-partner and partner-to-TUBB4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TUBB4A-low versus TUBB4A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBB4A→partner) and Y-score (partner→TUBB4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.363	+2.824	<.001	.034	3	3
UCEC	Notch1 →	+0.106	+1.498	.020	.032	3	2
UCEC	Annexin-1 →	+0.538	+2.434	.001	.001	3	2
UCEC	4E-BP1_pT37_T46 →	-0.334	-3.687	.006	.001	3	2
UCEC	C-Raf →	+0.140	+1.906	.002	.015	3	2
UCEC	A-Raf_pS299 →	-0.118	-2.247	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Caspase-7-cleavedD198 by TUBB4A expression — COAD

Explore this box plot interactively →