TUBB4A

Across TCGA patient cohorts, TUBB4A mutation is significantly associated with the RNA expression of many other genes, with 3,999 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TUBB4A-associated genes across cancer lineages are UHRF1, ERHP2, and LINC02683. Each is linked with TUBB4A in more than 2 cancer types. Because this analysis shows association rather than direction, both TUBB4A-to-partner and partner-to-TUBB4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UHRF1 grouped by TUBB4A-low versus TUBB4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TUBB4A→partner) and Y-score (partner→TUBB4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UHRF1 →	+0.707	+1.958	<.001	<.001	3	3
GBM	ERHP2 →	+0.257	+5.352	<.001	.005	3	3
PRAD	LINC02683 →	+0.329	+4.584	<.001	.001	3	3
COAD	RPA2 →	+0.554	+3.223	.001	.009	3	3
UCEC	KARS1 →	+0.422	+2.906	<.001	<.001	3	3
UCEC	LRRC42 →	+0.433	+1.847	.006	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,999 associations by consensus.

UHRF1 by TUBB4A expression — UCEC

Explore this box plot interactively →