SIN3 transcription regulator family member AGenealiases: CHR15DELq24 · DEL15Q24 · WITKOS
Q-omics provides the consensus-scored SIN3A profile across patient tissues and cancer cell-line models. SIN3A expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, SIN3A is differentially expressed in 10, with the highest sampling consensus in HNSC. Additionally, SIN3A protein abundance shows 28,597 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight KIRC, HNSC, and GBM as cancer lineages where SIN3A shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SIN3A — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SIN3A survival associations across molecular data types. SIN3A RNA expression shows survival associations in the most cancer types (21), followed by mutation status (7) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SIN3A RNA expression–survival associations across cancer types. High SIN3A expression shows unfavorable associations in ACC, UVM and PAAD, but favorable associations in KIRC, BRCA and SCLC. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for SIN3A RNA expression.
This table summarizes SIN3A tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 6. The strongest signals are observed in HNSC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for SIN3A. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SIN3A shows lower tumor expression in THCA and higher tumor expression in HNSC, LIHC, CHOL, STAD and LUSC. The HNSC box plot shows higher SIN3A RNA expression in tumor versus normal tissue (log2 FC = +0.854, t-test p < 0.001).
This table shows molecular features associated with SIN3A in patient tissues and cancer cell lines. In patient samples, SIN3A shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, SIN3A RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in OESOPHAGUS and BLOOD_Leukemia.
