SIN3A

Across TCGA pan-cancer cohorts, SIN3A mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SIN3A data layer compared with 21 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SIN3A mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SIN3A expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

HNSC, LSCC, and GBM are the cancer types where SIN3A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.786	0.908	.002	41	view →
LSCC	DFS	Tertile	All	0.888	0.558	.003	18	view →
GBM	OS	Tertile	All	0.499	0.262	.009	4	view →
CCRCC	DFS	Tertile	III,IV	1.000	0.492	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SIN3A–HNSC (OS)

Open the HNSC breakdown →