SIN3A

Across TCGA pan-cancer cohorts, SIN3A mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of SIN3A’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where SIN3A mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SIN3A is over-expressed in tumor.

CCRCC, HNSC, and LSCC are the cancer types where SIN3A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SIN3A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	All	+0.184	<.001	9	view →
HNSC	Male	All	+0.179	<.001	8	view →
LSCC	Male	All	+0.248	<.001	7	view →
COAD	Female	II,III,IV	+0.084	.013	3	view →
LUAD	Male	All	+0.111	<.001	2	view →
PDAC	Male	III,IV	+0.332	.008	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

SIN3A–CCRCC

Open the CCRCC breakdown →