SIN3A

Across TCGA cell cohorts, SIN3A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,530 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SIN3A-associated GO terms across cancer lineages are Negative regulation of gene expression, epigenetic, Nucleic acid transport, and RNA transport. Each is linked with SIN3A in more than 17 cancer types. Because this analysis shows association rather than direction, both SIN3A-to-partner and partner-to-SIN3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of gene expression, epigenetic grouped by SIN3A-low versus SIN3A-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIN3A→partner) and Y-score (partner→SIN3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of gene expression, epigenetic →	+0.089	+1.149	.005	<.001	3	18
BONE	Nucleic acid transport →	+0.144	+1.150	<.001	<.001	3	18
BONE	RNA transport →	+0.144	+1.150	<.001	<.001	3	18
SKIN	Establishment of RNA localization →	+0.089	+0.686	<.001	.001	3	18
BONE	Positive regulation of DNA metabolic process →	+0.066	+0.797	<.001	<.001	3	17
BLOOD_Myeloma	Nuclear transport →	+0.100	+1.148	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,530 associations by consensus.

Negative regulation of gene expression, epigenetic by SIN3A expression — BONE

Explore this box plot interactively →