SIN3A

Across TCGA pan-cancer cohorts, SIN3A Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SIN3A data layer compared with 21 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher SIN3A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SIN3A expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

THYM, UCEC, and BLCA are the cancer types where SIN3A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
UCEC	DFS	Median	All	0.979	0.609	<.001	34	view →
BLCA	DFS	Median	All	0.876	0.318	.002	26	view →
KIRC	OS	Median	All	0.138	0.655	.021	12	view →
KIRP	OS	Median	III,IV	0.220	0.810	<.001	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
SKCM	OS	Median	All	0.974	0.866	.030	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SIN3A–THYM (OS)

Open the THYM breakdown →