SIN3A

Across TCGA cell cohorts, SIN3A mutation is significantly associated with the RNA expression of many other genes, with 125 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIN3A-associated genes across cancer lineages are IFNA8, OR2W1, and IZUMO1R. Each is linked with SIN3A in more than 1 cancer types. Because this analysis shows association rather than direction, both SIN3A-to-partner and partner-to-SIN3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA8 grouped by SIN3A-low versus SIN3A-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIN3A→partner) and Y-score (partner→SIN3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	IFNA8 →	+0.052	+4.930	<.001	.008	3	1
SOFT_TISSUE	OR2W1 →	+0.023	+5.977	<.001	.001	3	1
UPPER_AERODIGESTIVE_TRACT	IZUMO1R →	+0.053	+4.736	<.001	.009	3	1
STOMACH	TRIM49D2 →	+0.040	+5.285	<.001	.003	3	1
LUNG_NSCLC_LUAD	FGF23 →	+0.107	+3.786	<.001	.001	3	1
LUNG_NSCLC_LUAD	MT1HL1 →	+0.086	+4.266	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 125 associations by consensus.

IFNA8 by SIN3A expression — SOFT_TISSUE

Explore this box plot interactively →