SIN3A

Across TCGA patient cohorts, SIN3A mutation is significantly associated with the total protein of many other genes, with 76 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIN3A-associated genes across cancer lineages are PAI-1, ATM, and Caspase-7-cleavedD198. Each is linked with SIN3A in more than 4 cancer types. Because this analysis shows association rather than direction, both SIN3A-to-partner and partner-to-SIN3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAI-1 grouped by SIN3A-low versus SIN3A-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIN3A→partner) and Y-score (partner→SIN3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	PAI-1 →	+0.861	+2.824	.021	.036	3	4
UCEC	ATM →	-0.486	-2.192	<.001	<.001	3	4
COAD	Caspase-7-cleavedD198 →	+0.842	+3.169	.005	.018	2	5
UCEC	Rad50 →	-0.224	-1.169	.001	.017	3	3
COAD	Tuberin →	-0.438	-1.691	<.001	.043	3	3
STAD	ERK2 →	+0.372	+3.000	.019	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 76 associations by consensus.

PAI-1 by SIN3A expression — BLCA

Explore this box plot interactively →