ras responsive element binding protein 1Genealiases: FINB · HNT · LZ321 · RREB-1 · Zep-1
Q-omics provides the consensus-scored RREB1 profile across patient tissues and cancer cell-line models. RREB1 expression is associated with patient survival in 27 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, RREB1 is differentially expressed in 10, with the highest sampling consensus in THCA. Additionally, RREB1 protein abundance shows 25,755 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight KIRC, THCA, and LSCC as cancer lineages where RREB1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RREB1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RREB1 survival associations across molecular data types. RREB1 RNA expression shows survival associations in the most cancer types (27), followed by mutation status (6) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RREB1 RNA expression–survival associations across cancer types. High RREB1 expression shows unfavorable associations in LGG, CESC and ACC, but favorable associations in KIRC, UVM and HNSC. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for RREB1 RNA expression.
This table summarizes RREB1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 6. The strongest signals are observed in THCA for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for RREB1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RREB1 shows lower tumor expression in THCA and COAD and higher tumor expression in LUSC, LIHC, STAD and CHOL. The THCA box plot shows higher RREB1 RNA expression in normal versus tumor tissue (log2 FC = −0.611, t-test p < 0.001).
This table shows molecular features associated with RREB1 in patient tissues and cancer cell lines. In patient samples, RREB1 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, RREB1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in URINARY_TRACT, while CRISPR and shRNA rows add functional-dependency signals in LIVER and LARGE_INTESTINE.
