RREB1

Across TCGA pan-cancer cohorts, RREB1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of RREB1’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where RREB1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types RREB1 is over-expressed in tumor, although a few such as CCRCC and PDAC show the opposite, repressed pattern.

LSCC, LUAD, and CCRCC are the cancer types where RREB1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RREB1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	III,IV	+0.512	<.001	9	view →
LUAD	Male	II,III,IV	+0.416	<.001	9	view →
CCRCC	Female	All	−0.195	<.001	7	view →
PDAC	Male	All	−0.421	<.001	6	view →
HNSC	All	All	−0.101	.021	2	view →
COAD	All	All	+0.131	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

RREB1–LSCC

Open the LSCC breakdown →