RREB1

Across TCGA cell cohorts, RREB1 mutation is significantly associated with the RNA expression of many other genes, with 711 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RREB1-associated genes across cancer lineages are TTI2, OR1L6, and H1-1. Each is linked with RREB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RREB1-to-partner and partner-to-RREB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTI2 grouped by RREB1-low versus RREB1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RREB1→partner) and Y-score (partner→RREB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TTI2 →	+0.407	+2.252	.002	.003	3	3
BONE	OR1L6 →	+0.020	+5.169	<.001	.004	3	2
SOFT_TISSUE	H1-1 →	+0.108	+3.637	.006	.002	3	2
SOFT_TISSUE	OR52H1 →	+0.024	+3.297	<.001	.008	3	2
OESOPHAGUS	CRYBB1 →	+0.026	+4.906	<.001	.006	3	2
PANCREAS	OTOL1 →	+0.016	+3.786	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 711 associations by consensus.

TTI2 by RREB1 expression — BLOOD_Leukemia

Explore this box plot interactively →