RREB1

Across TCGA pan-cancer cohorts, RREB1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RREB1 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher RREB1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RREB1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

LSCC, LUAD, and PDAC are the cancer types where RREB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.873	0.390	.002	37	view →
LUAD	DFS	Quartile	II,III,IV	0.096	0.700	.001	27	view →
PDAC	DFS	Tertile	All	0.312	0.570	.006	18	view →
UCEC	DFS	Quartile	II,III,IV	1.000	0.447	.018	8	view →
CCRCC	DFS	Median	IV	0.781	0.220	.017	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RREB1–LSCC (DFS)

Open the LSCC breakdown →