RREB1

Across TCGA patient cohorts, RREB1 mutation is significantly associated with the RNA expression of many other genes, with 6,768 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RREB1-associated genes across cancer lineages are CLEC1A, MIR4743, and CCM2L. Each is linked with RREB1 in more than 3 cancer types. Because this analysis shows association rather than direction, both RREB1-to-partner and partner-to-RREB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLEC1A grouped by RREB1-low versus RREB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RREB1→partner) and Y-score (partner→RREB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CLEC1A →	-0.236	-2.094	.001	<.001	3	4
BLCA	MIR4743 →	+0.183	+4.618	<.001	<.001	3	3
UCEC	CCM2L →	-0.424	-1.574	<.001	<.001	3	3
SKCM	CHCHD3 →	+0.441	+3.078	.002	<.001	3	3
LUAD	GTPBP4 →	+0.535	+3.345	.003	.005	3	3
LUAD	MTPAP →	+0.432	+2.541	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,768 associations by consensus.

CLEC1A by RREB1 expression — UCEC

Explore this box plot interactively →