RREB1

Across TCGA patient cohorts, RREB1 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RREB1-associated genes across cancer lineages are FoxM1, eIF4E, and Caspase-7-cleavedD198. Each is linked with RREB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RREB1-to-partner and partner-to-RREB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by RREB1-low versus RREB1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RREB1→partner) and Y-score (partner→RREB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FoxM1 →	+0.358	+2.840	.007	.033	3	3
UCEC	eIF4E →	+0.155	+1.874	.007	.002	3	3
UCEC	Caspase-7-cleavedD198 →	+0.607	+1.604	<.001	.002	3	3
LUAD	PREX1 →	-0.235	-3.169	.005	.019	3	2
LUAD	Bap1-c-4 →	+0.304	+2.832	.002	.034	2	3
LUAD	Chk2 →	+0.370	+3.169	.005	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

FoxM1 by RREB1 expression — LUAD

Explore this box plot interactively →