ring finger protein 40Genealiases: BRE1B · RBP95 · STARING
Q-omics provides the consensus-scored RNF40 profile across patient tissues and cancer cell-line models. RNF40 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in BLCA. Among the 18 cancer types available for tumor–normal comparison, RNF40 is differentially expressed in 13, with the highest sampling consensus in KIRP. Additionally, RNF40 protein abundance shows 26,142 significant protein co-abundance associations, with the highest sampling consensus in HNSC. Together, these results highlight BLCA, KIRP, and HNSC as cancer lineages where RNF40 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RNF40 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RNF40 survival associations across molecular data types. RNF40 RNA expression shows survival associations in the most cancer types (23), followed by mutation status (4) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RNF40 RNA expression–survival associations across cancer types. High RNF40 expression shows unfavorable associations in BLCA, LGG and MESO, but favorable associations in KIRC, UCS and ACC. The BLCA Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify BLCA as the clearest survival context for RNF40 RNA expression.
This table summarizes RNF40 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 7. The strongest signals are observed in HNSC for RNA and COAD for protein.
This table ranks reproducible tumor–normal expression differences for RNF40. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RNF40 shows lower tumor expression in THCA and higher tumor expression in KIRP, HNSC, LIHC, COAD and STAD. The KIRP box plot shows higher RNF40 RNA expression in tumor versus normal tissue (log2 FC = +0.913, t-test p < 0.001).
This table shows molecular features associated with RNF40 in patient tissues and cancer cell lines. In patient samples, RNF40 shows the broadest associations at the RNA and protein expression levels, with HNSC recurring as the lineage with the largest associated feature set. In cancer cell lines, RNF40 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OESOPHAGUS, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT and BLOOD_Lymphoma.
