RNF40

Across TCGA cell cohorts, RNF40 mutation is significantly associated with the RNA expression of many other genes, with 256 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RNF40-associated genes across cancer lineages are NPAP1, OR2A2, and TARM1. Each is linked with RNF40 in more than 1 cancer types. Because this analysis shows association rather than direction, both RNF40-to-partner and partner-to-RNF40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPAP1 grouped by RNF40-low versus RNF40-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF40→partner) and Y-score (partner→RNF40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	NPAP1 →	+0.013	+5.169	<.001	.005	3	2
URINARY_TRACT	OR2A2 →	+0.046	+5.087	<.001	.004	3	1
URINARY_TRACT	TARM1 →	+0.026	+5.087	<.001	.004	3	1
LARGE_INTESTINE	CCDC134 →	+0.597	+2.043	.007	.008	3	1
LARGE_INTESTINE	CCP110 →	+0.587	+2.743	.004	.001	3	1
LARGE_INTESTINE	IL27RA →	+0.869	+2.743	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 256 associations by consensus.

NPAP1 by RNF40 expression — BREAST

Explore this box plot interactively →