RNF40

Across TCGA pan-cancer cohorts, RNF40 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RNF40’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where RNF40 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNF40 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRP, HNSC, and THCA are the cancer types where RNF40 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF40 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+0.913	<.001	10	view →
HNSC	Male	All	+0.790	<.001	10	view →
THCA	All	II,III,IV	−0.687	<.001	9	view →
LIHC	All	All	+0.689	<.001	7	view →
COAD	All	All	+0.299	<.001	7	view →
STAD	Male	II,III,IV	+1.208	<.001	6	view →
BRCA	All	II,III,IV	+0.592	<.001	6	view →
BLCA	All	All	+0.474	.001	6	view →
KIRC	Female	All	+0.434	<.001	6	view →
LUAD	All	All	+0.353	<.001	6	view →
CHOL	All	All	+1.822	<.001	5	view →
LUSC	Male	All	+0.368	.002	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RNF40–KIRP

Open the KIRP breakdown →