RNF40

Across TCGA pan-cancer cohorts, RNF40 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RNF40 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher RNF40 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated RNF40 expression acts as an unfavorable survival marker, although some lineages such as GBM and UCEC show a favorable association.

GBM, UCEC, and LUAD are the cancer types where RNF40 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Quartile	All	0.530	0.315	.017	8	view →
UCEC	OS	Median	All	0.982	0.866	.032	6	view →
LUAD	OS	Median	III,IV	0.232	0.618	.040	2	view →
LSCC	OS	Median	All	0.889	0.738	.021	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RNF40–GBM (OS)

Open the GBM breakdown →