RNF40

Across TCGA pan-cancer cohorts, RNF40 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of RNF40’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where RNF40 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types RNF40 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

COAD, HNSC, and LSCC are the cancer types where RNF40 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNF40 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	+0.155	<.001	9	view →
HNSC	Male	IV	+0.310	<.001	8	view →
LSCC	Male	III,IV	+0.309	<.001	8	view →
LUAD	Male	III,IV	+0.168	<.001	7	view →
PDAC	Male	All	−0.177	.006	4	view →
CCRCC	Male	All	+0.043	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

RNF40–COAD

Open the COAD breakdown →