RNF40

Across TCGA patient cohorts, RNF40 mutation is significantly associated with the RNA expression of many other genes, with 2,879 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RNF40-associated genes across cancer lineages are LETM1, TRABD, and PPP2R2D. Each is linked with RNF40 in more than 2 cancer types. Because this analysis shows association rather than direction, both RNF40-to-partner and partner-to-RNF40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LETM1 grouped by RNF40-low versus RNF40-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RNF40→partner) and Y-score (partner→RNF40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LETM1 →	+0.520	+2.675	<.001	<.001	3	3
COAD	TRABD →	+0.519	+3.239	.009	.008	3	3
COAD	PPP2R2D →	+0.296	+3.665	.001	.001	3	3
UCEC	MCM10 →	+0.537	+2.346	.003	<.001	3	3
UCEC	RPL23AP82 →	+0.361	+2.078	<.001	<.001	3	3
UCEC	UBE2L3 →	+0.219	+2.256	.009	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,879 associations by consensus.

LETM1 by RNF40 expression — UCEC

Explore this box plot interactively →