microsomal triglyceride transfer proteinGenealiases: ABL · MTP
Q-omics provides the consensus-scored MTTP profile across patient tissues and cancer cell-line models. MTTP expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in UCEC. Among the 18 cancer types available for tumor–normal comparison, MTTP is differentially expressed in 12, with the highest sampling consensus in KIRP. Additionally, MTTP RNA expression shows 16,935 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight UCEC, KIRP, and UVM as cancer lineages where MTTP shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for MTTP — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes MTTP survival associations across molecular data types. MTTP RNA expression shows survival associations in the most cancer types (25), followed by mutation status (8) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible MTTP RNA expression–survival associations across cancer types. High MTTP expression shows unfavorable associations in UCEC, LGG and KIRP, but favorable associations in SKCM, ACC and OV. The UCEC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UCEC as the clearest survival context for MTTP RNA expression.
This table summarizes MTTP tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 3. The strongest signals are observed in KIRP for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for MTTP. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. MTTP shows lower tumor expression in KIRP, KICH, BLCA, KIRC, THCA and BRCA. The KIRP box plot shows higher MTTP RNA expression in normal versus tumor tissue (log2 FC = −2.229, t-test p < 0.001).
This table shows molecular features associated with MTTP in patient tissues and cancer cell lines. In patient samples, MTTP shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, MTTP RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Lymphoma, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and LIVER.
