MTTP

Across TCGA patient cohorts, MTTP mutation is significantly associated with the RNA expression of many other genes, with 6,555 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTTP-associated genes across cancer lineages are ZNF232, PUSL1, and GATB. Each is linked with MTTP in more than 3 cancer types. Because this analysis shows association rather than direction, both MTTP-to-partner and partner-to-MTTP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF232 grouped by MTTP-low versus MTTP-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTTP→partner) and Y-score (partner→MTTP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ZNF232 →	+0.909	+3.933	<.001	<.001	3	4
UCEC	PUSL1 →	+0.350	+2.070	.002	.001	3	4
UCEC	GATB →	+0.267	+1.794	.001	<.001	3	4
UCEC	NEK4 →	+0.658	+2.828	<.001	<.001	3	4
UCEC	PINK1-AS →	+0.448	+1.794	<.001	<.001	3	4
UCEC	SMU1 →	+0.430	+2.237	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,555 associations by consensus.

ZNF232 by MTTP expression — COAD

Explore this box plot interactively →