MTTP

Across TCGA pan-cancer cohorts, MTTP Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated MTTP data layer compared with 25 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher MTTP Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated MTTP expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

UCEC, STAD, and COAD are the cancer types where MTTP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.972	0.614	.003	32	view →
STAD	DFS	Median	All	1.000	0.390	.027	30	view →
COAD	OS	Median	All	0.227	0.700	<.001	25	view →
ACC	OS	Median	All	0.147	0.685	.018	12	view →
LIHC	OS	Median	II,III,IV	0.011	0.716	<.001	12	view →
PRAD	DFS	Median	All	0.666	0.936	.021	6	view →
ESCA	DFS	Median	II,III,IV	0.052	0.495	<.001	6	view →
SKCM	DFS	Median	II,III,IV	0.553	0.205	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

MTTP–UCEC (DFS)

Open the UCEC breakdown →