MTTP

Across TCGA patient cohorts, MTTP mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MTTP-associated genes across cancer lineages are C-Raf, c-Kit, and p38-MAPK_pT180_Y182. Each is linked with MTTP in more than 3 cancer types. Because this analysis shows association rather than direction, both MTTP-to-partner and partner-to-MTTP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by MTTP-low versus MTTP-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTTP→partner) and Y-score (partner→MTTP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	C-Raf →	+0.206	+2.853	.004	.034	3	4
BLCA	c-Kit →	-0.308	-2.999	.037	.035	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.377	-1.999	.006	.002	3	3
LUSC	Chk2_pT68 →	+0.163	+2.816	.013	.036	3	2
STAD	Cyclin-E2 →	+0.202	+2.828	.006	.035	2	3
UCEC	Caspase-8 →	-0.245	-2.780	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

C-Raf by MTTP expression — LUSC

Explore this box plot interactively →