MTTP

Across TCGA cell cohorts, MTTP mutation is significantly associated with the drug of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MTTP-associated genes across cancer lineages are Cytarabine, CDK9_5038, and AZD5991. Each is linked with MTTP in more than 1 cancer types. Because this analysis shows association rather than direction, both MTTP-to-partner and partner-to-MTTP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytarabine grouped by MTTP-low versus MTTP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MTTP→partner) and Y-score (partner→MTTP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Cytarabine →	+0.803	+2.655	.039	.044	3	1
LARGE_INTESTINE	CDK9_5038 →	+0.589	+3.129	.023	.014	3	1
LARGE_INTESTINE	AZD5991 →	+0.764	+2.871	.036	.021	3	1
LARGE_INTESTINE	ULK1_4989 →	+0.616	+2.871	.049	.021	3	1
LARGE_INTESTINE	VSP34_8731 →	+0.426	+2.871	.025	.021	3	1
LARGE_INTESTINE	Fulvestrant →	+0.324	+2.684	.046	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Cytarabine by MTTP expression — LARGE_INTESTINE

Explore this box plot interactively →